Even before snow began piling up, airlines reported weather-related delays and cancellations, with major airports in Chicago, Cleveland, Washington, D.C., and Newark, New Jersey scrubbing dozens of flights, according to the Federal Aviation Administration and FlightStats.com.
The heaviest accumulation was expected in central Pennsylvania, New York state and interior New England, which could see between 4 and 8 inches of snow. Mountainous areas and parts of eastern Maine could be walloped by a foot of snow.
The same region was slammed a week ago by another massive storm system that left parts of the Mid-Atlantic and East Coast shoveling out from a half-foot of snow.
Utility companies across the region put extra crews on duty and made preparations for possible outages.
New York City's Sanitation Department for a second Saturday issued a snow alert and prepared plows and salt spreaders to clear snowy, icy roads.
The brunt of bad weather will hit through Saturday with the system moving out of the area by Sunday, AccuWeather said. Slushy conditions on Sunday could freeze in cold evening temperatures.