The University of Louisville is the tournament's overall top seed and No. 1 seed in the Midwest region. The Cardinals have a 29-5 record after capturing a portion of the Big East regular season title and winning the conference tournament. The University of Kansas, at 29-5, is the South region's top seed by virtue of sharing the Big 12 conference regular season title and winning the conference tournament championship. In the West region, Gonzaga is the No. 1 seed after compiling a 31-2 mark and winning the West Coast conference tournament. Finally in the East region, Indiana is the number one seed. The Hoosiers, at 27-6, were the Big Ten regular season champions, and ranked No. 1 in the country for several weeks during the college basketball season.