But is it possible that Clinton might not give a White House campaign another try?
The former first lady, New York senator and US secretary of State has paid speeches lined up into 2015, including one scheduled in the middle of March. She often speaks of her affinity for her work at the Clinton Foundation and joy over becoming a grandmother for the first time.
Clinton also recognizes — with plenty of personal experience — the downsides of a presidential campaign. "We say, 'OK, get ready, put your armor on, run that gauntlet, see who survives at the end,' " Clinton said in a speech last year in San Francisco. "And whoever is standing up still, that's the winner."
To be sure, such musings are overshadowed by evidence that Clinton will run again. She has largely left the potential 2016 field frozen in place, locking down financial donors, endorsements, and connections around the country and in the early states like Iowa and New Hampshire.
Early polling shows her in a dominant position, outside groups have been promoting her candidacy for more than a year, and fundraising juggernaut EMILY's List has been laying a foundation for the campaign to elect the nation's first female president.
"It would be shocking," if Hillary didn't run, said Tad Devine, a Democratic strategist who is advising Vermont Sen. Bernie Sanders, a potential challenger.
But what if? Such a decision would set off a chaotic shuffle in the Democratic Party as candidates now considered long-shots become instant contenders and politicians now planning to skip the race give it a new look.
"It might be a good thing to open it up and have competition based on ideas, not that it's her turn," said Dick Harpootlian, the former chairman of the South Carolina Democratic Party. He added: "I think we could do very well without Hillary."
Here's a look at some whose political fortunes and plans for 2016 could change if Clinton decides to pass on the race.
In any other year, the sitting vice president would have an inside track to the nomination. But Clinton's dominant standing within the party has marginalized Biden in early 2016 discussion. In a Clinton-free campaign, the veteran of runs for president in 1988 and 2008 would be an early front-runner.
The Massachusetts senator is a favorite of liberal activists, some of whom are trying to "draft" her into running for president — even though she has repeatedly said she is not. Warren's populist economic approach and calls to rein in Wall Street resonate with many Democrats disappointed by the midterm elections and the gap between the wealthy and the poor. If Clinton decides not to run, Warren is sure to face pressure to fill the void.
The outgoing Maryland governor has been a workhorse surrogate for fellow Democrats, trying to build a network of financial donors — only to be effectively frozen by Clinton. Even without Clinton in the field, the Republicans' defeat of his hand-picked successor in Maryland — and sagging poll ratings at the end of his term — would complicate his campaign.
The former Virginia senator would bring a bipartisan record to the campaign: he served as President Ronald Reagan's Navy secretary. He is an accomplished author and decorated veteran, still carrying shrapnel from his service in the Vietnam War. Independent and at times unpredictable, his foreign policy outlook and outsider status could shake up the primary with or without Clinton.
Few Democrats expect the independent senator from Vermont to make much of an impact if he runs against Clinton, but that has not stopped Sanders from courting college students and liberals in Iowa and New Hampshire. He has maintained a large email distribution list, giving him a way of reaching activists, but is still more likely to shape the debate than compete for delegates no matter what Clinton does.
When former New York Gov. Mario Cuomo declined to seek the White House in 1991 after a lengthy deliberation, the vacuum helped a relatively-unknown Arkansas governor named Bill Clinton. If Hillary Rodham Clinton decides not to run, it could give his son, current New York Gov. Andrew Cuomo, an opening to jump into a race he does not plan to contest. The second-term governor has built a record of accomplishments on marriage equality, gun control and, last month, banned hydraulic fracturing in New York — a move cheered by environmentalists.
The Virginia senator has big-time credentials: He's a Spanish-speaking former Catholic missionary, Harvard Law graduate, former mayor of Richmond, Virginia, and the ex-governor of the state. Kaine quickly embraced candidate Barack Obama and found himself on the short-list for vice president. Instead, Obama put him in charge of the Democratic National Committee and Kaine later succeeded Webb in the Senate. He has backed the pro-Clinton Ready for Hillary super PAC, and would get a serious look if Clinton took a pass.
The energetic New Yorker holds Clinton's old Senate seat and has been talked up as a potential heir apparent. A relative newcomer to the national stage, Gillibrand has displayed a strong acumen as a legislator, fundraising moxie, and a down-to-earth sensibility as the constantly juggling mother of two boys. She has championed legislation to remove sexual assault cases from the military chain of command and promoted paid family leave for women.
The first woman elected to the Senate from Minnesota, Klobuchar has made political trips to neighboring Iowa to help Democratic candidates and the party, moves that always start talk about the White House. A former prosecutor, Klobuchar has built a reputation in the Senate for working across the aisle. On the dinner circuit, she displays a folksy sense of humor that helps her connect with Democratic audiences.
The former Vermont governor and contender for the party's 2004 presidential nomination has backed Clinton, giving the former secretary of state an advocate among the party's liberal wing. As DNC chairman, Dean helped modernize the party's technological capabilities, laying the ground work for Obama's successful grassroots campaign in 2008. He's unlikely to leave the private sector, but may be swayed if Clinton decided to take a pass on another campaign.
Follow Ken Thomas on Twitter: https://twitter.com/KThomasDC