Wild horse genome reveals hidden costs of domestication

Captive breeding has helped preserve the last breed of wild horse on Earth, but it has also altered the Przewalksi horse's gene pool.

Courtesy of Claudia Feh/Association pour le cheval de Przewalski
Reintroduced Przewalski's horses graze on the Seer reserve in Khomiin Tal, Mongolia.

The world’s last wild horses, the Przewalksi’s horses, might help us understand the effect domestication has on a genomic scale.

Przewalksi’s horses, discovered in the 1870s in the Asian steppes, are the planet’s closest thing to wild horses. They faced extinction, but due to a committed conservation effort in the 1960s, more than 2,000 individuals remain. Most of them are living in reintroduction reserves.

A research team, including Ludovic Orlando of the University of Copenhagen’s Natural History Museum of Denmark, sequenced the complete genomes of eleven of the remaining wild horses and five historical, museum specimens. They compared them to the genomes of 28 domesticated horses. In this way the team is able to “assess the genetic impact of more than 100 years of captivity in what used to be a critically endangered animal,” as Dr. Orlando told Sci-News.

The findings, which are published by in the journal Current Biology, show that 110 years of captivity have had a negative impact on the Przewalksi horses. The horses had lower genetic diversity and increased inbreeding. They also had signs of domesticated genes, hinting that domesticated horses might have mixed with the breed.

The greatest genetic differences between domesticated and wild horses appeared to involve metabolism, cardiac disorders, behavior, reproduction, muscle contraction, and signaling pathways, according to a press release.

Orlando did have some good news for the horses: "Even though Przewalski's horses went through an extreme demographic collapse, the population seems to recover, and is still genetically diverse… There is, thus, hope for endangered populations, fighting similar demographic issues."

This study is the latest in Orlando’s quest to map out the genetic changes of domestication. In 2014, he conducted a similar study investigating which genes were favored as horses turned from wild animals to humans’ companions.

As Arne Ludwig of the Leibniz Institute for Zoo and Wildlife Research told Reuters in response to Orlando’s last study, “Comparing ancient genomes to modern genomes is tricky.”

You've read  of  free articles. Subscribe to continue.
Real news can be honest, hopeful, credible, constructive.
What is the Monitor difference? Tackling the tough headlines – with humanity. Listening to sources – with respect. Seeing the story that others are missing by reporting what so often gets overlooked: the values that connect us. That’s Monitor reporting – news that changes how you see the world.

Dear Reader,

About a year ago, I happened upon this statement about the Monitor in the Harvard Business Review – under the charming heading of “do things that don’t interest you”:

“Many things that end up” being meaningful, writes social scientist Joseph Grenny, “have come from conference workshops, articles, or online videos that began as a chore and ended with an insight. My work in Kenya, for example, was heavily influenced by a Christian Science Monitor article I had forced myself to read 10 years earlier. Sometimes, we call things ‘boring’ simply because they lie outside the box we are currently in.”

If you were to come up with a punchline to a joke about the Monitor, that would probably be it. We’re seen as being global, fair, insightful, and perhaps a bit too earnest. We’re the bran muffin of journalism.

But you know what? We change lives. And I’m going to argue that we change lives precisely because we force open that too-small box that most human beings think they live in.

The Monitor is a peculiar little publication that’s hard for the world to figure out. We’re run by a church, but we’re not only for church members and we’re not about converting people. We’re known as being fair even as the world becomes as polarized as at any time since the newspaper’s founding in 1908.

We have a mission beyond circulation, we want to bridge divides. We’re about kicking down the door of thought everywhere and saying, “You are bigger and more capable than you realize. And we can prove it.”

If you’re looking for bran muffin journalism, you can subscribe to the Monitor for $15. You’ll get the Monitor Weekly magazine, the Monitor Daily email, and unlimited access to CSMonitor.com.

QR Code to Wild horse genome reveals hidden costs of domestication
Read this article in
QR Code to Subscription page
Start your subscription today