Speaking to reporters afterwards, Wiesel said the meeting was a "good kosher lunch" between friends. But he said the conversation did turn serious, as the two Nobel Peace Prize winners discussed the administration's attempts to break the deadlock in the Israel-Palestinian peace talks.
Obama's meeting with Wiesel, a strong supporter of Israel, comes during a period of strained relations between the U.S. and Israel. The author said he believes tensions between the two countries are lessening.
"Relations between Israel and the United States have a history, and that history has always been one of understanding," he said.
Wiesel visited the White House last February when he accepted an award for his work to educate the country on the Holocaust.
Wiesel won the Nobel Peace Prize in 1986. Obama won last year.