Romo may be missing one of his favorite targets in wide receiver Miles Austin, who was also injured against the 49ers.
On defense, the Redskins are improved, led by linebacker London Fletcher and cornerback DeAngelo Hall. They are expected to bring pressure in some form on every play against Romo and the Cowboys offensive line.
So far this season, the Redskins offense is riding the steady play of quarterback Rex Grossman, who's thrown for nearly 600 yards and four touchdowns in Washington's first two games. Running back Tim Hightower has provided a strong presence on the ground with 168 yards rushing.
Grossman will be facing a Dallas defense that is ranked fifth overall in the National Football League. The latest installment of the NFC East rivalry kicks off at 8 p.m. ET Monday on ESPN from Cowboys Stadium outside Dallas.