White, 89, will lead a group of seven senior citizens who play pranks on others in the program that is based on the popular European television show, "Benidorm Bastards."
"People have been telling me that I'm 'Off My Rocker' for years -- now I can prove it," White said in a statement announcing the upcoming show.
Her flair for comedy has made White as popular as ever in recent years portraying kindly older women who have a mean or mischievous streak. A comedy series in which she currently stars, "Hot in Cleveland," has been renewed for a third season.
NBC said it had ordered 12 episodes of "Betty White's Off Their Rockers," but did not say when the show would begin airing on the network.