Ms. Bullock was named favorite movie actress, favorite comedic actress, favorite dramatic actress, and she shared the favorite movie duo award with "Gravity" co-star George Clooney. Bullock's buddy comedy, "The Heat," co-starring Melissa McCarthy, won favorite comedic movie.
Kat Dennings and Beth Behrs, stars of TV's "2 Broke Girls," hosted the show at the Nokia Theatre.
Fans chose Ellen DeGeneres as their favorite daytime TV host, making her the woman with the most People's Choice Awards: 14 trophies.
"As a young girl growing up in New Orleans, if anyone would have told me I was going to win 14 People's Choice Awards I...I mean 12, yes. 13, maybe. But 14?" joked Ms. DeGeneres, host of "The Ellen DeGeneres Show," who said that she wanted to make the show for everyone – old, young, black, white, gay, and straight.
"Iron Man 3" scored three awards: favorite movie, favorite action movie, and favorite action movie star Robert Downey Jr., who channeled Iron Man in his acceptance speech.
Justin Timberlake also nabbed three awards. Among them was the favorite album accolade for "The 20/20 Experience." In a sweet moment, he thanked his "beautiful wife" Jessica Biel, "for teaching me patience and the little things like just putting the dishes in the dishwasher. It goes a long way. Fellas, you're welcome."
Katy Perry, who was not at the show, scored the win for favorite video for "Roar." She has won this award three years running, for "Last Friday Night" in 2012 and "Part of Me" in 2013.
A pregnant Drew Barrymore, who joked that DeGeneres had called her fat backstage, presented her "Blended" co-star Adam Sandler with the comedic movie actor award.
Queen Latifah won the award for favorite new talk show host for "The Queen Latifah Show," which debuted in 2013
Ian Somerhalder and Nina Dobrev, the stars of "The Vampire Diaries," earned the award for best on-screen chemistry. The duo, who had their round of breakups and makeups on-screen and off, joked about their coupledom.
"The good thing is chemistry," said Dobrev, with her arm around Somerhalder, whom she is no longer romantically attached to.
Shemar Moore heavily hit on fellow presenter Malin Akerman, cracking jokes about ebony and ivory and saying he didn't see a ring on her finger. She played right along, leaning in as the crowd cheered them on.
Stephen Colbert won the favorite late night talk show host award, Britney Spears picked up the favorite pop artist honor, and Kaley Cuoco received the favorite comedic TV actress prize as well as the favorite TV comedy award, along with the rest of the cast of "The Big Bang Theory."
Sara Bareilles performed her hit "Brave," country star Brad Paisley took the stage to sing "The Mona Lisa," and OneRepublic sang "Counting Stars."
Jennifer Hudson won the show's second-ever humanitarian award for her work with children via her Julian D. King Gift Foundation. Bullock gained the show's first humanitarian award in 2013 for her efforts in storm-ravaged New Orleans.
Accompanied on stage by her sister Julia, Ms. Hudson, accepted the favorite humanitarian award while holding back tears. "My mother always taught us without family you have nothing," Hudson said. "Whether you know it or not, we all are family. What happens to the other happens to us. It's one thing to be a celebrity and have power, but it means nothing if we're not making a difference and helping someone else. It feels good to see positivity acknowledged. Where we come from all you hear about is who shot who and who went to jail. There is more to life than the block you live on. We want to show them that I came from the same area and if I can do it, you can do it too."
LL Cool J presented Hudson with the award. The Oscar-winning actress created the Chicago-based Julian D. King Gift Foundation with her sister, Julia Hudson, in honor of their nephew, Julian King, who was murdered in 2008 at the age of 7.