The crew, which is being commanded by retired 53-year old Russian Air Force Col. Padalka, will immediately get to work preparing for the arrival next week of privately owned SpaceX's Dragon Capsule. It will be the first time a private company has launched space station supplies.
Padalka is a seasoned space traveler, having spent a total of 585 days in space on three previous missions on board the now-defunct Mir station and the current International Space Station. Inglewood, California-native Acaba, who turns 45 on Thursday, on the day that Soyuz is due to dock, makes his second venture into space after his maiden orbital voyage on the shuttle in 2009. Revin, 46, is making his first trip to space.
Until NASA either brings a new craft online or private companies are able to arrange manned trips to the orbiting station, the Soviet-designed Soyuz spacecraft will remain the only means to deliver crews to the orbiting outpost.
The Russian space program has been blighted by a string of technical glitches in the recent past, raising questions over its dependability.
Tuesday's launch had been pushed back by two months due to depressurization of the spacecraft's descent module during the ground testing phase. It was the second significant postponement of a manned Russian launch in the space of a year.
A Russian Mars moon probe crashed to Earth in January in what the nation's space agency described as the result of cosmic radiation.
That came only weeks after the crash of a communications satellite and the crash in August of a supply ship destined for the space station.