Serena Williams entered the day with a 46-0 record in first-round matches at Grand Slam tournaments. Serena Williams lost Virginie Razzano of France 4-6, 7-6 (5), 6-3 Tuesday at the French Open.
Maria Sharapova, the No. 2 seed, easily beat Alexandra Cadantu of Romania 6-0, 6-0 in the first round of the French Open. With a French Open victory, Sharapova would notch a career Grand Slam.