He vows to support a regional treaty to curb gun trafficking as well as greater cooperation on clean energy.
He's likely to stress shared responsibility for rising border violence during trip that begins Thursday.
Ousted governor pleaded not guilty to federal charges on Tuesday, as political watchdogs tally cost of state's long history of graft and cronyism.
Most are, say US officials. But the NRA says the Obama administration is inflating the scope of the problem and threatens to undermine the Second Amendment.
In recent years, states have barred undocumented students from getting the lower tuition fees.
The country has put steep tariffs on an array of goods. Seventeen of the world's 20 largest economies have broken recent promises not to take protectionist measures.
Homeland Security Secretary Janet Napolitano and Attorney General Eric Holder visit Mexico Thursday to meet with their counterparts.