Analysts and Afghans worry that the killing of Kandahar powerbroker Ahmad Wali Karzai will destabilize Afghanistan's south, which has seen major security gains this year.
While insurgent-caused casualties are up, US-caused civilian casualties are down. Still, it only takes a couple of high profile incidents to negatively turn public opinion.
The results of Saturday's Afghanistan election aren't expected for days, but because the parliamentary candidates ran as individuals, not as party members, they are unlikely to unite in opposition to President Hamid Karzai.
The Kabul Bank is a bedrock for a stable Afghan society. Its collapse could spell disaster for the country already battling a resurgent Afghan Taliban.
Even before Tuesday's suicide attack in Kandahar killed three US soldiers and five Afghan civilians, the view from Kandahar was that the Afghanistan war wasn’t going well.