The president addressed extremism, the Israeli-Palestinian conflict, women's rights, and nuclear proliferation, among other topics.
Many welcomed the US president's conciliatory tone and references to Islamic history. Skeptics pointed to the price Pakistan pays for ongoing US involvement in Afghanistan.
'The absence in his speech of any bellicose threats to Iran stands in stark contrast to his predecessor,' says a Muslim politician in Birmingham.
Obama criticized Holocaust deniers. But Ayatollah Khamenei praised US effort at a "new image."
A Lebanese-French international relations specialist says Obama set a new tone. But there were few specifics on Israeli-Palestinian solutions.
'The Muslim world has been waiting for a long time for such thing.'
His speech should aim to launch a new dialogue between two estranged communities of the world, some regional experts say.
A new tone can defuse 'residual anger' among Muslims over the Iraq war, but it's likely to hit its limits in dealing with Iran.