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| Name | Website | Category | Total Income in Millions (2006) | Public Support in Millions (2006) | Percent of Total Expenses Spent on Programs | Salary & Benefits of Highest Paid Official† | AIP Grade‡ | Wise Giving Alliance‡‡ | Charity Navigator |
| ALSAC/St. Jude's Children's Research Hospital | stjude.org | Hospital/Med center | 568.8 | 496.6 | 76.4 | 535849 | B+ | Y | **** |
| Academy for Educational Development | aed.org | Education | 335.2 | 49.6 | 89.8 | 364949 | N/A | N/A | N/A |
| AmeriCares Foundation | americares.org | Relief/Development | 888.7 | 884.6 | 99.2 | 275000 | A | Y | **** |
| America's Second Harvest | secondharvest.org | Social services | 653.2 | 644.3 | 98.1 | 403116 | A | Y | **** |
| American Cancer Society | cancer.org | Health | 1037.7 | 969.3 | 54.5 | 654176 | C+ | Y | ** |
| American Heart Association | americanheart.org | Health | 589.1 | 445.5 | 76.5 | 860640 | C | Y | ** |
| American Jewish Joint Distribution Committee | jdc.org | Relief/Development | 252.2 | 234.5 | 92.9 | 379000 | N/A | Y | *** |
| American Red Cross | redcross.org | Social services | 6008.6 | 3138.3 | 94.2 | 440022 | A+ | Y | **** |
| Art Institute of Chicago | artic.edu | Civic/cultural | 259.1 | 80.9 | 84.6 | 361985 | N/A | N/A | ** |
| Baptist Health South Florida | baptisthealth.net | Health | 481.7 | 107.9 | 70.5 | 70032 | N/A | N/A | N/A |
| Big Brothers/Big Sisters of America | bbbsa.org | Youth | 274.0 | 182.9 | 78.3 | 267733 | A+ | Y | **** |
| Boy Scouts of America | scouting.org | Youth | 1077.4 | 425.6 | 87.1 | 589143 | A+/B ‡‡‡ | Y | ** |
| Boys & Girls Clubs of America | bgca.org | Youth | 1448.8 | 664.4 | 80.2 | 552032 | A– | Y | **** |
| Brother's Brother Foundation | brothersbrother.org | Relief/Development | 267.3 | 266.2 | 99.8 | 98000 | A | Y | **** |
| CARE | care.org | Relief/Development | 655.4 | 249.6 | 91.7 | 196829 | A | N/A | **** |
| Campus Crusade for Christ | ccci.org | Religious | 499.4 | 453.6 | 85.3 | 69466 | N/A | N | N/A |
| Catholic Charities USA | catholiccharitiesusa.org | Social services | 3586.2 | 721.1 | 90.1 | 186570 | N/A | Y | **** |
| Catholic Relief Services | catholicrelief.org | Relief/Development | 573.4 | 220.2 | 94.0 | 250000 | A+ | Y | N/A |
| Children's Hospital of Los Angeles | childrenshospitalla.org | Hospital/Med center | 527.8 | 61.5 | 76.7 | 1289646 | N/A | N/A | N/A |
| City of Hope and affiliates | cityofhope.org | Hospital/Med center | 640.9 | 132.3 | 84.1 | 1086092 | A– | N/A | **** |
| Compassion International | compassion.com | Relief/Development | 257.6 | 256.7 | 83.8 | 184990 | A | Y | **** |
| Dana-Farber Cancer Institute | dfci.harvard.edu | Hospital/Med center | 698.3 | 228.7 | 90.1 | 659696 | N/A | N/A | **** |
| Eisenhower Medical Center | emc.org | Hospital/Med center | 360.5 | 42.0 | 85.1 | 556073 | N/A | N/A | N/A |
| Feed the Children | feedthechildren.org | Relief/Development | 649.8 | 637.0 | 87.1 | 195388 | F | Y | **** |
| Food For The Poor | foodforthepoor.org | Relief/Development | 861.8 | 836.4 | 96.2 | 301200 | C– | Y | **** |
| Gifts in Kind International | giftsinkind.org | Product donations | 897.0 | 892.8 | 99.9 | 166113 | A– | Y | N/A |
| Girl Scouts of the USA* | girlscouts.org | Youth | 781.0 | 143.0 | 83.6 | 446816 | A– | Y | *** |
| Goodwill Industries International | goodwill.org | Social services | 3260.1 | 454.8 | 88.0 | 348593 | B | Y | N/A |
| Habitat for Humanity | habitat.org | Social services | 1150.0 | 700.0 | 80.8 | 169645 | A– | N/A | **** |
| MAP International | map.org | Health | 253.8 | 250.0 | 98.6 | 117615 | C | Y | **** |
| Memorial Sloan-Kettering Cancer Center | mskcc.org | Hospital/Med center | 1837.9 | 1656.2 | 87.3 | 2491450 | A | N | N/A |
| Metropolitan Museum of Art | metmuseum.org | Museums | 466.6 | 108.9 | 89.0 | 4557342 | N/A | N/A | **** |
| Museum Of Modern Art | moma.org | Museums | 263.7 | 133.5 | 79.5 | 901766 | N/A | N/A | **** |
| Museum of Fine Arts, Houston | mfah.org | Museums | 295.2 | 185.8 | 86.2 | 850000 | N/A | N | **** |
| National Easter Seal Society | easterseals.com | Health | 992.4 | 112.0 | 86.9 | 551300 | B– | N/A | *** |
| Nature Conservancy | nature.org | Environment | 1010.4 | 517.9 | 78.3 | 375000 | A– | Y | *** |
| New York Public Library | nypl.org | Libraries | 287.1 | 51.4 | 87.5 | 484432 | N/A | N/A | *** |
| Planned Parenthood Federation of America | plannedparenthood.org | Health | 899.6 | 207.6 | 82.8 | 284147 | A | Y | ** |
| Public Broadcasting Service | pbs.org | Public broadcasting | 540.3 | 285.8 | 95.9 | 702621 | N/A | N/A | N/A |
| Samaritan's Purse | samaritanspurse.org | Relief/Development | 276.3 | 260.2 | 89.9 | 261613 | B+ | N/A | **** |
| Save the Children Federation | savethechildren.org | Relief/Development | 349.7 | 196.6 | 90.1 | 304997 | A | Y | **** |
| Shriners Hospitals for Children | shrinershq.org | Hospital/Med center | 735.8 | 243.8 | 90.8 | 1175034 | A+/F ‡‡‡ | N | *** |
| Smithsonian Institution | si.edu | Museums | 581.5 | 131.2 | 81.8 | 587742 | N/A | N/A | *** |
| The Salvation Army | salvationarmyusa.org | Social services | 3293.4 | 1626.5 | 83.4 | 171670 | A | Y | N/A |
| United Jewish Communities** | ujc.org | Jewish federation | 4300.0 | 3300.0 | 81.9 | 536000 | N/A | N | N/A |
| United States Fund for UNICEF | unicefusa.org | Relief/Development | 370.3 | 356.2 | 90.0 | 429135 | A | Y | **** |
| Volunteers of America | voa.org | Social Services | 860.4 | 95.9 | 88.5 | 289506 | N/A | N/A | *** |
| World Vision | wvi.org | Relief/Development | 945.8 | 671.7 | 86.6 | 313000 | A– | N/A | **** |
| YMCA of the USA | ymca.net | Social services | 5697.5 | 960.3 | 81.6 | 381199 | A | N | ** |
| YWCA of the USA* | ywca.org | Social services | 542.6 | 445.5 | 83.5 | 180559 | B–/F ‡‡‡ | N/A | * |