Most of this ad is your standard fare. The candidate expresses his willingness to do "whatever it takes," and it closes with the obligatory "I'm-not-a-fuddy-duddy" shot of a woman with a stud in her nose. But what's with the gag at the beginning about "Twitter" being slang for an embarrassing malady? Your guess is as good as ours.
To be sure, the Iowa senator's campaign Twitter feed is active, and it's clear that he writes all of his own tweets. Chuck Grassley also has a ... Facebook account. Don't be surprised if, in addition to retaining his Senate seat, he also wins a few Foursquare mayorships.