Gloria Cain (née Etchison), of Atlanta, married now-businessman and radio host Herman Cain after she graduated from Morris Brown College in 1968. Ms. Cain is a homemaker; she also has worked as a teacher and a librarian. The Cains have two children and three grandchildren. Mr. Cain has said of his wife, who avoids the spotlight, 'My wife represents that calm and tranquility that I look forward to seeing when I get home.' David Goldman/AP/File
Ann Romney, born Ann Lois Davies, originally from Michigan, married now-businessman and former governor of Massachusetts Mitt Romney in 1966. She converted to his religion, The Church of Jesus Christ of Latter-day Saints, in 1966. They have five children. In 1998, she was diagnosed with multiple sclerosis. While serving as Massachusetts First Lady, she was the governor's liaison for federal faith-based initiatives. She has been a visible presence in all of Mr. Romney's campaigns. Jim Cole/AP
Lifelong Texan Anita Thigpen Perry, now retired from the nursing profession, is the First Lady of Texas and married to Gov. Rick Perry in 1982. As First Lady, she has been an advocate for nursing and other health care issues. The Perrys met as children at an elementary school piano recital. They have two children. Ms. Perry is an outspoken supporter of her husband's campaign and has helped open campaign offices and held town halls with potential voters. Brian Snyder/Reuters/File
Carol Wells married Ron Paul, who represents Texas's 14th congressional district, in Pittsburgh in 1957. They have five children, including son Rand, who is the junior senator from Kentucky. Ms. Paul has worked as a secretary and dance instructor, among other jobs, to contribute to family finances over the years. She talks to Mr. Paul two to three times a day while he is campaigning and makes him chocolate chip cookies to take on the road. Jim Young/Reuters/File
Callista Louise Gingrich, née Bisek, is the third wife of former Speaker of the United States House of Representatives Newt Gingrich and the president of Gingrich Productions, a multimedia production company based in Washington. The couple married in 2000. Originally from Wisconsin, Ms. Gingrich worked in Washington for the US House of Representatives, the House Committee on Agriculture, and Wisconsin Congressman Steve Gunderson. Jim Cole/AP/File
Mary Kaye Huntsman, who hails from Orlando, Fla., was born Mary Kaye Cooper. She met future husband Jon Hunstman, former Governor of Utah, in high school after her family moved to Salt Lake City, Utah. They married in 1983 and have seven children, two of whom are adopted. An activist, Ms. Huntsman has developed programs to help children and teenagers. She has said she is behind her husband's campaign '100 percent.' Cheryl Senter/AP
In 1978, Marcus Bachmann married Michele Marie Bachmann, née Amble, now a Minnesota congresswoman and presidential candidate. Mr. Bachmann is a clinical therapist who runs a Christian counseling center. The couple has five children and also have provided foster care for 23 other children, all teenaged girls. On his website, Mr. Bachmann states, 'I believe my call is to minister to the needs of people in a practical, effective, and sensitive way. Christ is the Almighty Counselor.' Charlie Neibergall/AP
Karen Garver Santorum and her husband, former Pennsylvania senator Rick Santorum, married in 1990 and have seven children. Ms. Santorum is the author of a book on etiquette for children entitled 'Everyday Graces: A Child's Book Of Good Manners.' She is closely involved with her husband's campaign and has said that the 2010 presidential race is not just another political race: 'It’s about going on to the battlefield and defending God’s truth in the world.'